Everything about Abl Gene totally explained
,,,,,,,,,,,,,,,,,,,,,,,,,,,,
| Name = V-abl Abelson murine leukemia viral oncogene homolog 1
| HGNCid = 76
| Symbol = ABL1
| AltSymbols =; ABL; JTK7; bcr/abl; c-ABL; p150; v-abl
| OMIM = 189980
| ECnumber =
| Homologene = 3783
| MGIid = 87859
| GeneAtlas_image1 = PBB_GE_ABL1_202123_s_at_tn.png
| Function =
| Component =
| Process =
| Orthologs =
}}
The
abl gene is associated with
chronic myelogenous leukemia (CML). The abl gene is located on the 9th
chromosome. In CML, the gene is activated by being
translocated within the bcr (breakpoint cluster region)
gene on chromosome 22. This new abl/bcr (chimeric) gene encodes an unregulated, cytoplasm targetted tyrosine kinase which allows the cells to proliferate without being regulated by
cytokines. This in turn allows the cell to become
cancerous.
This gene is fused with the
bcr gene in a
Philadelphia chromosome, the characteristic abnormality in
chronic myelogenous leukemia (CML) and rarely in some other
leukemia forms. The
bcr-abl transcript is also a
tyrosine kinase, which activates mediators of the
cell cycle regulation system, leading to a clonal
myeloproliferative disorder. The
bcr-abl protein can be inhibited with the agent
imatinib mesylate, which occupies the
TK domain and inhibits
bcr-abls influence on the cell cycle.
Further Information
Get more info on 'Abl Gene'.
|
External Link Exchanges
Do you know how hard it is to get a link from a large encyclopaedia? Well we're different and will prove it. To get a link from us just add the following HTML to your site on a relevant page:
<a href="http://abl_gene.totallyexplained.com">Abl gene Totally Explained</a>
Then simply click through this link from your web page. Our crawlers will verify your link, extract the title of your web page and instantly add a link back to it. If you like you can remove the words Totally Explained and embed the link in article text.
As long as your link remains in place, we'll keep our link to you right here. Please play fair - our crawlers are watching. Your site must be closely related to this one's topic. Any kind of spamming, dubious practises or removing the link will result in your link from us being dropped and, potentially, your whole site being banned. |
